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Shah, Jigna S.
- Interlinking Between Altered Thyroid State and Development of Insulin Resistance: A Review
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Authors
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1 Shri Sarvajanik Pharmacy College, Mehsana-384001, IN
2 Shri Sarvajanik Pharmacy College, Mehsana, IN
3 L. M. College of Pharmacy, Ahmedabad, IN
1 Shri Sarvajanik Pharmacy College, Mehsana-384001, IN
2 Shri Sarvajanik Pharmacy College, Mehsana, IN
3 L. M. College of Pharmacy, Ahmedabad, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 3, No 5 (2011), Pagination: 234-240Abstract
It has long been recognized that thyroid hormones have marked effects on glucose homeostasis. Glucose intolerance is associated with hyperthyroidism and most recently it was shown that hypothyroidism is characterized by insulin resistance (IR). The interaction between thyroid function and insulin sensitivity is an important contributor to diabetic dyslipidemia. Effect of thyroid status on insulin sensitivity is of great interest but despite various studies reveal conflicting data on this subject. Thyroid disorders, including both hypo- and hyperthyroidism, may be associated with IR due to a plethora mechanism like, increased FFA, accumulation of intramyocellular lipids (IMCLs), increase in (Tumor Necrosis Factor)TNF-α, altered peripheral glucose disposal, altered blood flow, impaired GLUT4 translocation, decreased glycogen synthesis, down regulated intracellular glucose catabolism, decreased muscle oxidative capacity and many more contributing factors.Keywords
Insulin Resistance, Hyperthyroidism, Hypothyroidism, Thyroid Hormones.
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- P-Glycoprotein - A Unique Transporter Pump
Abstract Views :211 |
PDF Views:2
Authors
Affiliations
1 Shri Sarvajanik Pharmacy College, Mehsana, Gujarat, IN
2 Shri Sarvajanik Pharmacy College, Mehsana, IN
3 L. M. College of Pharmacy, Ahmedabad, IN
1 Shri Sarvajanik Pharmacy College, Mehsana, Gujarat, IN
2 Shri Sarvajanik Pharmacy College, Mehsana, IN
3 L. M. College of Pharmacy, Ahmedabad, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 3, No 5 (2011), Pagination: 241-245Abstract
P-Glycoprotein (P-gp)/MDR1 is the 170-kDa ABC drug transporter protein. It is a member of the ABC(ATP Binding Cassette)super family.It is involved in limiting the harmful exposure of toxins, drugs, and xenobiotics to the body by extruding them into the gastrointestinal tract, bile and urine. Drugs or substrates can cross into the cell membrane by simple diffusion, filtration, or by specialized transport. The first step in drug efflux is drug recognition by P-gp followed by ATP-binding and subsequent hydrolysis. Finally, the generated energy is utilized to efflux substrate outside the cell membrane through central pore. P-gp acts as a rate limiting step during various stages of pharmacokinetic of drug but mainly on the absorption. Different drugs have different impact on P-gp expression. Some drugs are substrate of p-gp while some are inducers or inhibitors of P-gp. Altered P-gp/MDR1 activity due to induction and/or inhibition can cause drug-drug interactions with altered drug pharmacokinetics and response of drug. P-gpmayshow gender basis differences and so drug effect in individuals.References
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- Significance of Estrogen in Acute Coronary Syndrome
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Authors
Affiliations
1 Shri Sarvajanik Pharmacy College, Mehsana-384001, Gujarat, IN
2 Shri Sarvajanik Pharmacy College, Mehsana, IN
3 L. M. College of Pharmacy, Ahmedabad, IN
4 Care Institute of Medical Sciences, Ahmedabad, IN
1 Shri Sarvajanik Pharmacy College, Mehsana-384001, Gujarat, IN
2 Shri Sarvajanik Pharmacy College, Mehsana, IN
3 L. M. College of Pharmacy, Ahmedabad, IN
4 Care Institute of Medical Sciences, Ahmedabad, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 3, No 4 (2011), Pagination: 210-214Abstract
Estrogen, a cardioprotective agent, potentiates acetylcholine-induced increase in coronary blood flow, decreases coronary endothelin-1 levels, reduces ischemia, enhances fibrinolysis, shifts markers of coagulation toward hypercoagulability, and increases blood levels of matrix metalloproteinase-9, involved in plaque disruption and inflammatory markers like interleukin-6 and C-reactive protein. Rates of cardiovascular disease in women tend to rise during menopause, when estrogen level decreases. Hormone replacement therapy (HRT) provides exogenous estrogen to encounter the deficiency of estrogen into body, which demonstrates favorable cardioprotective effects, if initiated few years within the onset of menopause. However, use of HRT is controversial in preventing progression of the diseases at the later stages; since it cannot repair the damage already occurred. The therapy reduces the progression rate of atherosclerosis in post-menopausal women, who are not suffering from cardiovascular disease. However, in patients with cardiovascular disease or risk factors, estrogen therapy enhances cardiac events.Keywords
Estrogen, Hormone Replacement Therapy, Cardiovascular Disease, Menopause.References
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- Embryonal Rhabdomyosarcoma as a Gingival Growth:A Rare Presentation
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Authors
Affiliations
1 Department of Oral Medicine and Radiology, Government Dental College and Hospital, Asarwa, Ahmedabad - 380016, Gujarat, IN
1 Department of Oral Medicine and Radiology, Government Dental College and Hospital, Asarwa, Ahmedabad - 380016, Gujarat, IN
Source
Journal of Pierre Fauchard Academy (India Section), Vol 33, No 2 (2019), Pagination: 59-63Abstract
Rhabdomyosarcoma (RMS) is a malignant tumor of striated muscle composed of neoplastic mesenchymal cells with varying degrees of cell differentiation. It accounts 60% of all soft-tissue sarcomas in children and only 2-5% in adults. Typical pediatric rhabdomyosarcoma variants like embryonal and alveolar sub-types are less frequently occur in adults. It has predilection for viscera followed by the head and neck region. RMS occurs in the head and neck region with 35% and 10-12% in the oral cavity. Establishment of the correct diagnosis and histological sub-type is of very importance in the treatment of this disease, because of the rarity of this neoplasm in the adult population the treatment is not uniform in the literature. Here we present case of embryonal rhabdomyosarcoma as a gingival growth in a 26-year-old female with clinical, radiological, histo-pathological and immunohistochemical aspects.
Keywords
Embryonal, Rhabdomyosarcoma, Sarcomas.References
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- Extraoral Sublingual Epidermoid Cyst: A Case Report
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Authors
Affiliations
1 Department of Oral Medicine and Radiology, Government Dental College and Hospital, Asarwa, Ahmedabad - 380016, Gujarat, IN
2 Department of Dentistry, R.H and C.H.C, Gadat, Tapi, Vyara, Gujarat, IN
1 Department of Oral Medicine and Radiology, Government Dental College and Hospital, Asarwa, Ahmedabad - 380016, Gujarat, IN
2 Department of Dentistry, R.H and C.H.C, Gadat, Tapi, Vyara, Gujarat, IN
Source
Journal of Pierre Fauchard Academy (India Section), Vol 34, No 3 (2020), Pagination: 103-106Abstract
Epidermoid Cysts (EC) are rare cysts of the head and neck region, which may confuse with many soft tissue sublingual mass pathologies. A presentation of such cyst is important to decide the surgical approach. The aim of this paper was to present the role of USG and MRI for determine the surgical approach. A female patient presented with chronic asymptomatic swelling over left submandibular neck which was single diffuse, non-tender, soft, compressible, fluctuant with normal overlying skin. Swelling was not movable with deglutination and protrusion of tongue. MRI and USG guided FNAC was conclusive to diagnose the lesion. Histological examination confirmed the diagnosis. Lateral neck swelling should be considered as EC for differential diagnosis. A careful physical examination and fine needle aspiration and diagnostic imaging should be performed which clarifies the surgical approach.
Keywords
Epidermoid Cyst, Lateral Neck Swelling, Ultrasound, FNAC, MRI.References
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